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interleukin-12 subunit alpha; IL-12A; cytotoxic lymphocyte maturation factor 35 kD subunit; CLMF p35; IL-12 subunit p35; NK cell stimulatory factor chain 1; NKSF1 (IL12A, NKSF1)
Function:
- cytokine
- can act as a growth factor for activated T-cells & NK cells, enhance lytic activity of NK/lymphokine-activated killer cells, & stimulate production of IFN-gamma by resting lymphocytes
- heterodimer with IL12B, disulfide-linked as interleukin IL-12
Structure: belongs to the IL-6 superfamily
Compartment: secreted
Pathology:
- down-regulated in response to enterovirus 71 (EV71) infection
General
glycoprotein
human longevity protein
protein subunit
Properties
SIZE: entity length = 219 aa
MW = 25 kD
MOTIF: signal sequence {1-22}
cysteine residue {C64}
MODIFICATION: cysteine residue {C196}
cysteine residue {C85}
MODIFICATION: cysteine residue {C123}
N-glycosylation site {N93}
cysteine residue {C96}
MODIFICATION: cysteine residue {C199 IN IL12B}
N-glycosylation site {N107}
cysteine residue {C123}
MODIFICATION: cysteine residue {C85}
cysteine residue {C196}
MODIFICATION: cysteine residue {C64}
Database Correlations
OMIM 161560
UniProt P29459
Pfam PF03039
Entrez Gene 3592
Kegg hsa:3592
References
- UniProt :accession P29459
- Wikipedia; Note: interleukin-12 entry
http://en.wikipedia.org/wiki/interleukin_12
- SeattleSNPs
http://pga.gs.washington.edu/data/il12a/
Component-of
interleukin-12; cytotoxic lymphocyte maturation factor; NK cell stimulatory factor (IL12, IL-12)