interferon-stimulated 20 kD exonuclease-like 1 (apoptosis enhancing nuclease, ISG20L1, AEN, SBBI58)

Function: - may contribute to radiation response during ionizing radiation induced apoptosis by cooperatively cleaving DNA substrates along with other apoptotic nucleases & ehance apoptosis Structure: contains 1 exonuclease domain Compartment: - nucleus - pronounced perinuclear localization at 1 hour after post-irradiation Alternative splicing: named isoforms=2 Expression: induced by ionizing radiation

General

exonuclease nuclear protein

Properties

SIZE: entity length = 325 aa MW = 36 kD COMPARTMENT: cell nucleus MOTIF: Exonuclease {110-266}

Database Correlations

UniProt Q8WTP8 Pfam PF00929 Kegg hsa:6478

References

UniProt :accession Q8WTP8