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interferon regulatory factor 6 (IRF6)

Structure: - belongs to the IRF family - contains 1 tryptophan pentad repeat DNA-binding domain Compartment: nucleus (putative) Pathology: - defects in IRF6 are a cause of: a) van der Woude syndrome b) popliteal pterygium syndrome c) non-syndromic orofacial cleft type 6

General

interferon regulatory factor family

Properties

SIZE: MW = 53 kD entity length = 467 aa COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 9-111

Database Correlations

OMIM correlations MORBIDMAP 607199 UniProt O14896 Pfam PF00605 Entrez Gene 3664 Kegg hsa:3664

References

  1. UniProt :accession O14896
  2. Entrez Gene :accession 3664
  3. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=IRF6