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interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2, IRF-2BP2, IRF2BP2)
Function:
- acts as a transcriptional repressor
- acts as a transcriptional corepressor (IRF2-dependent)
- repression is not mediated by histone deacetylase
- interacts with IRF2
- part of a corepressor complex containing IRF2 & IRF2BP1
Structure:
- C-terminal RING-type Zn+2 finger domain is necessary for interaction with BAP1
- belongs to the IRF2BP family
- contains 1 RING-type Zn+2 finger
Compartment: nucleus
Alternative splicing: named isoforms=3
General
ring finger protein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 587 aa
MW = 61 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 104-200
MOTIF: proline residue (SEVERAL)
RING-finger {506-550}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Database Correlations
UniProt Q7Z5L9
Pfam PF00097
References
UniProt :accession Q7Z5L9