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interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1, IRF-2BP1, IRF2BP1)
Function: acts as a transcriptional repressor
- acts as a transcriptional corepressor (RF2-dependent)
- repression is not mediated histone deacetylase
- interacts with IRF2
- part of a corepressor complex containing IRF2 & IRF2BP2
Structure:
- C-terminal RING-type Zn+2 finger domain is necessary for interaction with BAP1
- belongs to the IRF2BP family
- contains 1 RING-type Zn+2 finger
Compartment: nucleus
General
phosphoprotein
ring finger protein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 584 aa
MW = 62 kD
COMPARTMENT: cell nucleus
MOTIF: coiled coil {197-217}
Ser phosphorylation site {S421}
Ser phosphorylation site {S436}
Ser phosphorylation site {S453}
RING-finger {503-550}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Database Correlations
UniProt Q8IU81
Kegg hsa:2614
References
UniProt :accession Q8IU81