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interferon regulatory factor 2 (IRF2)
Function:
- specifically binds to the upstream regulatory region of type 1 IFN & IFN-inducible MHC class 1 genes (the interferon consensus sequence, ICS) & represses those genes
- interacts with BRD7, IRF2BP1 & IRF2BP2
Structure:
- belongs to the IRF family
- contains 1 tryptophan pentad repeat DNA-binding domain
Compartment: nucleus
Expression: induced by viruses & IFN
General
interferon regulatory factor family
Properties
SIZE: MW = 39 kD
entity length = 349 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 7-109
Database Correlations
OMIM 147576
UniProt P14316
Pfam PF00605
Entrez Gene 3660
Kegg hsa:3660
References
- UniProt :accession P14316
- Entrez Gene :accession 3660