interferon-inducible protein AIM2; absent in melanoma 2 (AIM2)

Function: - tumor suppressor - may act by repressing NF-kappa-B transcriptional activity - homodimer Structure: - belongs to the HIN-200 family - contains 1 DAPIN domain - contains 1 HIN-200 domain Compartment: nucleus Expression: - expressed in spleen, small intestine, peripheral blood leukocytes, & testis - induced by IFNG/IFN-gamma Pathology: - defects in AIM2 may be a cause of microsatellite instabilty in colon cancer

Properties

SIZE: entity length = 343 aa MW = 39 kD COMPARTMENT: cell nucleus MOTIF: DAPIN domain {1-87} HIN-200 domain {138-337}

Database Correlations

OMIM 604578 UniProt O14862 PFAM correlations Kegg hsa:9447

References

UniProt :accession O14828