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interferon consensus sequence binding protein 1; interferon response element binding protein (ICSBP, IRF8, ICSBP1)
Function:
- specifically binds to the upstream regulatory region of type 1 IFN & IFN-inducible MHC class 1 genes (the interferon consensus sequence (ICS)
- plays a negative regulatory role in cells of the immune system
- interacts with COPS2
Structure:
- belongs to the IRF family
- contains 1 tryptophan pentad repeat DNA-binding domain
Compartment: nucleus
Expression:
- predominantly in lymphoid tissues
- induced by interferon gamma
General
interferon regulatory factor family
Properties
SIZE: MW = 48 kD
entity length = 426 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 9-110
Database Correlations
OMIM 601565
UniProt Q02556
Pfam PF00605
Entrez Gene 3394
Kegg hsa:3394
References
- UniProt :accession Q02556
- Entrez Gene :accession 3394