intercellular adhesion molecule 5 (ICAM-5, telencephalin, ICAM5, TLCN, TLN)

Function: 1) adhesion molecule 2) binds to leukocyte adhesion LFA-1 protein (integrin alpha-L/integrin beta-2) Compartment: membrane Expression: - expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon

General

adhesion receptor glycoprotein

Properties

SIZE: MW = 97 kD entity length = 924 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-31} immunoglobulin superfamily domain {48-130} MOTIF: N-glycosylation site {N54} cysteine residue {C55} MODIFICATION: cysteine residue {C103} N-glycosylation site {N74} cysteine residue {C103} MODIFICATION: cysteine residue {C55} immunoglobulin superfamily domain {135-235} MOTIF: N-glycosylation site {N137} cysteine residue {C142} MODIFICATION: cysteine residue {C198} Thr phosphorylation site {T182} Thr phosphorylation site {T184} N-glycosylation site {N195} cysteine residue {C198} MODIFICATION: cysteine residue {C142} N-glycosylation site {N214} immunoglobulin superfamily domain {242-329} MOTIF: cysteine residue {C249} MODIFICATION: cysteine residue {C302} cysteine residue {C302} MODIFICATION: cysteine residue {C249} N-glycosylation site {N303} N-glycosylation site {N316} immunoglobulin superfamily domain {337-402} MOTIF: cysteine residue {C344} MODIFICATION: cysteine residue {C383} N-glycosylation site {N371} cysteine residue {C383} MODIFICATION: cysteine residue {C344} N-glycosylation site {N397} immunoglobulin superfamily domain {408-486} MOTIF: cysteine residue {C415} MODIFICATION: cysteine residue {C470} cysteine residue {C470} MODIFICATION: cysteine residue {C415} immunoglobulin superfamily domain {491-568} MOTIF: cysteine residue {C498} MODIFICATION: cysteine residue {C552} cysteine residue {C552} MODIFICATION: cysteine residue {C498} immunoglobulin superfamily domain {573-662} MOTIF: cysteine residue {C580} MODIFICATION: cysteine residue {C645} N-glycosylation site {N583} cysteine residue {C645} MODIFICATION: cysteine residue {C580} N-glycosylation site {N646} immunoglobulin superfamily domain {666-739} MOTIF: cysteine residue {C673} MODIFICATION: cysteine residue {C725} cysteine residue {C725} MODIFICATION: cysteine residue {C673} immunoglobulin superfamily domain {746-830} MOTIF: N-glycosylation site {N764} cysteine residue {C769} MODIFICATION: cysteine residue {C814} N-glycosylation site {N795} N-glycosylation site {N796} cysteine residue {C814} MODIFICATION: cysteine residue {C769} transmembrane domain {836-856}

Database Correlations

OMIM 601852 UniProt Q9UMF0 PFAM correlations

References

UniProt :accession Q9UMF0