integrin-beta 8 (ITGB8)

Function: - associates with integrin alpha-V (integrin alpha-V/beta-8) Structure: - belongs to the integrin beta chain family - contains 1 VWFA domain Compartment: membrane Expression: - placenta, kidney, brain, ovary, uterus & in several transformed cells - transiently expressed in 293 human embryonic kidney cells

General

glycoprotein integrin-beta

Properties

SIZE: entity length = 769 aa MW = 86 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-42} cysteine residue {C47} MODIFICATION: cysteine residue {C469} cysteine residue {C55} MODIFICATION: cysteine residue {C65} cysteine residue {C58} MODIFICATION: cysteine residue {C94} cysteine residue {C65} MODIFICATION: cysteine residue {C55} cysteine residue {C68} MODIFICATION: cysteine residue {C83} cysteine residue {C83} MODIFICATION: cysteine residue {C68} cysteine residue {C94} MODIFICATION: cysteine residue {C58} VWFA domain {146-384} MOTIF: cysteine residue {C211} MODIFICATION: cysteine residue {C218} cysteine residue {C218} MODIFICATION: cysteine residue {C211} N-glycosylation site {N233} cysteine residue {C266} MODIFICATION: cysteine residue {C307} cysteine residue {C307} MODIFICATION: cysteine residue {C266} N-glycosylation site {N402} cysteine residue {C407} MODIFICATION: cysteine residue {C419} cysteine residue {C419} MODIFICATION: cysteine residue {C407} N-glycosylation site {N421} N-glycosylation site {N431} N-glycosylation site {N456} N-glycosylation site {N466} cysteine residue {C467} MODIFICATION: cysteine residue {C471} cysteine residue {C469} MODIFICATION: cysteine residue {C47} Cysteine-rich tandem repeats {471-629} MOTIF: consensus repeat {471-510} cysteine residue {C471} MODIFICATION: cysteine residue {C467} cysteine residue {C494} MODIFICATION: cysteine residue {C499} cysteine residue {C499} MODIFICATION: cysteine residue {C494} consensus repeat {511-552} cysteine residue {C526} MODIFICATION: cysteine residue {C531} cysteine residue {C528} MODIFICATION: cysteine residue {C561} cysteine residue {C531} MODIFICATION: cysteine residue {C526} cysteine residue {C533} MODIFICATION: cysteine residue {C546} cysteine residue {C546} MODIFICATION: cysteine residue {C533} consensus repeat {553-592} cysteine residue {C561} MODIFICATION: cysteine residue {C528} cysteine residue {C567} MODIFICATION: cysteine residue {C572} cysteine residue {C572} MODIFICATION: cysteine residue {C567} cysteine residue {C574} MODIFICATION: cysteine residue {C583} cysteine residue {C583} MODIFICATION: cysteine residue {C574} cysteine residue {C585} MODIFICATION: cysteine residue {C593} consensus repeat {593-629} cysteine residue {C593} MODIFICATION: cysteine residue {C585} cysteine residue {C607} MODIFICATION: cysteine residue {C612} cysteine residue {C609} MODIFICATION: cysteine residue {C657} cysteine residue {C612} MODIFICATION: cysteine residue {C607} cysteine residue {C614} MODIFICATION: cysteine residue {C624} cysteine residue {C624} MODIFICATION: cysteine residue {C614} cysteine residue {C627} MODIFICATION: cysteine residue {C630} cysteine residue {C630} MODIFICATION: cysteine residue {C627} cysteine residue {C634} MODIFICATION: cysteine residue {C643} cysteine residue {C643} MODIFICATION: cysteine residue {C634} N-glycosylation site {N648} cysteine residue {C657} MODIFICATION: cysteine residue {C609} transmembrane domain {685-704}

Database Correlations

OMIM 604160 UniProt P26012 PFAM correlations Entrez Gene 3696 Kegg hsa:3696