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CD61 (integrin-beta 3, platelet membrane glycoprotein IIIA, GPIIIA, ITGB3, GP3A)

Function: - associates with integrin alpha-2b (CD41) in integrin alpha-2b/beta-3 Expression: - platelets, megakaryocytes Pathology: - defects associated with Glanzmann thrombasthenia - expressed in AML M7, some cases of AML M6 - AML M0 - AML M5 & most AML M6 stain negatively with antibody Laboratory: - HPA-1 type in blood - HPA-4 type in blood - HPA-6 type in blood Comparative Biology: - in vitro & in mice, integrin alpha-V/beta-3 is a marker of breast carcinoma, lung carcinoma, & pancreatic carcinoma - such cells have stem-like properties & are highly resistant to receptor tyrosine kinase inhibitors such as erlotinib - in the unbound state, integrin alpha-V/beta-3 recruits KRAS & RalB to the tumor cell plasma membrane, leading to activation of TBK1 & NF-kappaB

Related

ITGB3 gene mutation

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein integrin-beta

Properties

SIZE: entity length = 788 aa MW = 87 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-26} cysteine residue {C31} MODIFICATION: cysteine residue {C461} cysteine residue {C39} MODIFICATION: cysteine residue {C49} cysteine residue {C42} MODIFICATION: cysteine residue {C75} cysteine residue {C49} MODIFICATION: cysteine residue {C39} cysteine residue {C52} MODIFICATION: cysteine residue {C64} cysteine residue {C64} MODIFICATION: cysteine residue {C52} cysteine residue {C75} MODIFICATION: cysteine residue {C42} N-glycosylation site {N125} VWFA domain {135-377} MOTIF: cysteine residue {C203} MODIFICATION: cysteine residue {C210} cysteine residue {C210} MODIFICATION: cysteine residue {C203} cysteine residue {C258} MODIFICATION: cysteine residue {C299} cysteine residue {C299} MODIFICATION: cysteine residue {C258} N-glycosylation site {N346} N-glycosylation site {N397} cysteine residue {C400} MODIFICATION: cysteine residue {C412} cysteine residue {C412} MODIFICATION: cysteine residue {C400} cysteine residue {C432} MODIFICATION: cysteine residue {C681} cysteine residue {C459} MODIFICATION: cysteine residue {C463} cysteine residue {C461} MODIFICATION: cysteine residue {C31} Cysteine-rich tandem repeats {463-629} MOTIF: consensus repeat {463-511} cysteine residue {C463} MODIFICATION: cysteine residue {C459} cysteine residue {C474} MODIFICATION: cysteine residue {C486} N-glycosylation site {N478} cysteine residue {C483} MODIFICATION: cysteine residue {C521} cysteine residue {C486} MODIFICATION: cysteine residue {C474} cysteine residue {C488} MODIFICATION: cysteine residue {C497} cysteine residue {C497} MODIFICATION: cysteine residue {C488} cysteine residue {C499} MODIFICATION: cysteine residue {C512} consensus repeat {512-553} cysteine residue {C512} MODIFICATION: cysteine residue {C499} cysteine residue {C521} MODIFICATION: cysteine residue {C483} cysteine residue {C527} MODIFICATION: cysteine residue {C532} cysteine residue {C529} MODIFICATION: cysteine residue {C562} cysteine residue {C532} MODIFICATION: cysteine residue {C527} cysteine residue {C534} MODIFICATION: cysteine residue {C547} cysteine residue {C547} MODIFICATION: cysteine residue {C534} cysteine residue {C549} MODIFICATION: cysteine residue {C554} consensus repeat {554-592} cysteine residue {C554} MODIFICATION: cysteine residue {C549} cysteine residue {C562} MODIFICATION: cysteine residue {C529} cysteine residue {C568} MODIFICATION: cysteine residue {C573} cysteine residue {C570} MODIFICATION: cysteine residue {C601} cysteine residue {C573} MODIFICATION: cysteine residue {C568} cysteine residue {C575} MODIFICATION: cysteine residue {C584} cysteine residue {C584} MODIFICATION: cysteine residue {C575} N-glycosylation site {N585} cysteine residue {C586} MODIFICATION: cysteine residue {C593} consensus repeat {593-629} cysteine residue {C593} MODIFICATION: cysteine residue {C586} cysteine residue {C601} MODIFICATION: cysteine residue {C570} cysteine residue {C607} MODIFICATION: cysteine residue {C612} cysteine residue {C609} MODIFICATION: cysteine residue {C657} cysteine residue {C612} MODIFICATION: cysteine residue {C607} cysteine residue {C614} MODIFICATION: cysteine residue {C624} cysteine residue {C624} MODIFICATION: cysteine residue {C614} cysteine residue {C627} MODIFICATION: cysteine residue {C630} cysteine residue {C630} MODIFICATION: cysteine residue {C627} cysteine residue {C634} MODIFICATION: cysteine residue {C643} cysteine residue {C640} MODIFICATION: cysteine residue {C713} cysteine residue {C643} MODIFICATION: cysteine residue {C634} cysteine residue {C657} MODIFICATION: cysteine residue {C609} cysteine residue {C661} MODIFICATION: cysteine residue {C689} N-glycosylation site {N680} cysteine residue {C681} MODIFICATION: cysteine residue {C432} cysteine residue {C689} MODIFICATION: cysteine residue {C661} cysteine residue {C713} MODIFICATION: cysteine residue {C640} transmembrane domain {719-741} Tyr phosphorylation site {Y773} Thr phosphorylation site {T779} Tyr phosphorylation site {Y785}

Database Correlations

OMIM correlations MORBIDMAP 173470 UniProt P05106 PFAM correlations Entrez Gene 3690 Kegg hsa:3690

References

  1. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
  2. Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: 7716514
  3. http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
  4. Entrez Gene :accession 3690
  5. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ITGB3
  6. SHMPD; Note: The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ITGB3
  7. UniProt :accession P05106

Component-of

integrin alpha-V/beta-3