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integrin-beta
Function:
- regulatory subunit of integrins
- target integrins to focal adhesions (ligand-dependent)
Structure:
- composed of alpha & beta subunits selected from 16 alpha & 8 beta subunits that heterodimerize to produce more than 20 different receptors [3]
- the short cytoplasmic domains of the alpha & beta subunits do not have intrinsic enzyme activity, but appear to function by nucleating large complexes of cytoskeletal proteins & cytoskeletal-associated protein kinases
- integrin beta-4 is the exception, with a cytoplasmic domain in excess of 1000 residues
- integrin-alpha(s) contain highly divergent amino acid sequences, whereas the integrin-beta subunits show partial sequence conservation
- the integrin-beta(s) target integrins to focal adhesions in a ligand-independent manner, whereas the integrin-alpha(s) regulate the specificity of ligand-dependent interactions
Specific
CD104 (integrin-beta 4, GP150, ITGB4)
CD18 (integrin beta-2, L-CAM beta, ITGB2, CD18, MFI7)
CD29; integrin-beta 1; fibronectin receptor beta; platelet glycoprotein IIa; VLA-4 beta (ITGB1, FNRB, MDF2, MSK12)
CD61 (integrin-beta 3, platelet membrane glycoprotein IIIA, GPIIIA, ITGB3, GP3A)
integrin-beta 5 (ITGB5)
integrin-beta 6 (ITGB6)
integrin-beta 7 (ITGB7)
integrin-beta 8 (ITGB8)
General
cytoskeletal protein
membrane protein
protein subunit
Properties
MOTIF: binding site
FOR-BINDING-OF: RGD cell-attachment sequence
cysteine-rich region
transmembrane domain
binding site
SITE: C-TERMINAL
FOR-BINDING-OF: cytoskeletal protein
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 921
- Stossel TP.
On the crawling of animal cells.
Science. 1993 May 21;260(5111):1086-94. Review.
PMID: 8493552
- Clark EA & Brugge JS
Integrins and signal transduction pathways: the road taken.
Science 268:233 1995
PMID: 7716514
Component-of
integrin