CD41; integrin alpha-IIb; platelet membrane glycoprotein IIb (ITGA2B, GP2B, ITGAB)

Function: - associated with integrin beta-3 (integrin alpha-2b/beta-3) Structure: - composed of an heavy & a light chain linked by a disulfide bond - belongs to the integrin alpha chain family - contains 7 FG-GAP repeats Compartment: membrane Alternative splicing: named isoforms=3 Expression: - isoform 1 & isoform 2 were identified in platelets & megakaryocytes, but not in reticulocytes or in Jurkat & U937 white blood cell line - isoform 3 is expressed by leukemia, prostate adenocarcinoma & melanoma cells but not by platelets or normal prostate or breast epithelial cells Pathology: - polymorphism: a) position 874 is associated with platelet-specific alloantigen HPA-3/BAK/LEK b) HPA-3A/BAK(A)/LEK(A) has Ile-874 & HPA-3B/BAK(B)/LEK(B) has Ser-874 c) HPA-3B is involved in neonatal alloimmune thrombocytopenia - defects in ITGA2B are a cause of Glanzmann thrombasthenia - expressed in AML-M7 Laboratory: - HPA-3 type in blood

Related

CD41-Bf Ag in tissue ITGA2B gene mutation

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein integrin-alpha

Properties

SIZE: entity length = 1039 aa MW = 113 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-31} N-glycosylation site {N46} FG-GAP {47-107} MOTIF: cysteine residue {C87} MODIFICATION: cysteine residue {C96} cysteine residue {C96} MODIFICATION: cysteine residue {C87} consensus repeat {108} SEQUENCE-IS: FG-GAP cysteine residue {C138} MODIFICATION: cysteine residue {C161} cysteine residue {C161} MODIFICATION: cysteine residue {C138} cysteine residue {C177} MODIFICATION: cysteine residue {C198} cysteine residue {C198} MODIFICATION: cysteine residue {C177} consensus repeat {262} SEQUENCE-IS: FG-GAP FG-GAP {263-316} MOTIF: Ca+2-binding site SITE: 274-282 N-glycosylation site {N280} FG-GAP {317-384} MOTIF: Ca+2-binding site SITE: 328-336 FG-GAP {385-444} MOTIF: Ca+2-binding site SITE: 396-404 FG-GAP {445-497} MOTIF: Ca+2-binding site SITE: 457-465 cysteine residue {C504} MODIFICATION: cysteine residue {C515} cysteine residue {C515} MODIFICATION: cysteine residue {C504} cysteine residue {C521} MODIFICATION: cysteine residue {C576} cysteine residue {C576} MODIFICATION: cysteine residue {C521} N-glycosylation site {N601} cysteine residue {C633} MODIFICATION: cysteine residue {C639} cysteine residue {C639} MODIFICATION: cysteine residue {C633} cysteine residue {C705} MODIFICATION: cysteine residue {C718} N-glycosylation site {N711} cysteine residue {C718} MODIFICATION: cysteine residue {C705} cysteine residue {C857} MODIFICATION: cysteine residue {C-INTERCHAIN} Ser glycosylation site {S878} cysteine residue {C916} MODIFICATION: cysteine residue {C921} cysteine residue {C921} MODIFICATION: cysteine residue {C916} N-glycosylation site {N962} transmembrane domain {994-1019} GFFKR {1022-1026}

Database Correlations

OMIM correlations MORBIDMAP 607759 UniProt P08514 PFAM correlations