integrin alpha-9 (integrin alpha-RLC, ITGA9)

Function: - associates with integrin beta-1 (integrin alpha-9/beta-1) Structure: - belongs to the integrin alpha chain family - contains 7 FG-GAP repeats Compartment: membrane Expression: - expressed in airway epithelium - expressed in the basal layer of squamous epithelium - expressed in smooth muscle, skeletal muscle, & hepatocytes - abundantly expressed in fetal lung & lung cancers Pathology: up-regulated in small cell lung cancers (SCLC)

Properties

SIZE: entity length = 1035 aa MW = 115 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-29} FG-GAP {45-108} MOTIF: cysteine residue {C87} MODIFICATION: cysteine residue {C97} cysteine residue {C97} MODIFICATION: cysteine residue {C87} consensus repeat {109} SEQUENCE-IS: FG-GAP cysteine residue {C142} MODIFICATION: cysteine residue {C162} cysteine residue {C162} MODIFICATION: cysteine residue {C142} cysteine residue {C179} MODIFICATION: cysteine residue {C194} FG-GAP {187-243} MOTIF: cysteine residue {C194} MODIFICATION: cysteine residue {C179} N-glycosylation site {N225} FG-GAP {244-299} FG-GAP {301-360} MOTIF: Ca+2-binding site SITE: 312-320 FG-GAP {361-420} MOTIF: Ca+2-binding site SITE: 373-381 FG-GAP {423-477} MOTIF: Ca+2-binding site SITE: 435-443 N-glycosylation site {N476} cysteine residue {C482} MODIFICATION: cysteine residue {C491} cysteine residue {C491} MODIFICATION: cysteine residue {C482} N-glycosylation site {N493} cysteine residue {C497} MODIFICATION: cysteine residue {C555} cysteine residue {C555} MODIFICATION: cysteine residue {C497} peptide motif {565-566} N-glycosylation site {N612} cysteine residue {C620} MODIFICATION: cysteine residue {C625} cysteine residue {C625} MODIFICATION: cysteine residue {C620} N-glycosylation site {N654} N-glycosylation site {N658} N-glycosylation site {N672} N-glycosylation site {N676} cysteine residue {C696} MODIFICATION: cysteine residue {C706} cysteine residue {C706} MODIFICATION: cysteine residue {C696} N-glycosylation site {N807} N-glycosylation site {N854} cysteine residue {C855} MODIFICATION: cysteine residue {C891} cysteine residue {C891} MODIFICATION: cysteine residue {C855} cysteine residue {C898} MODIFICATION: cysteine residue {C903} cysteine residue {C903} MODIFICATION: cysteine residue {C898} N-glycosylation site {N904} transmembrane domain {982-1002} GFFKR {1005-1009}

Database Correlations

OMIM 603963 UniProt Q13797 PFAM correlations Entrez Gene 3680 Kegg hsa:3680