integrin alpha-8 (ITGA8)

Function: - associates with integrin beta-1 (integrin alpha-8/beta-1) Structure: - composed of an heavy & a light chain linked by a disulfide bond - belongs to the integrin alpha chain family - contains 7 FG-GAP repeats Compartment: membrane Expression: - expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells & hepatic stellar cells & vascular & visceral smooth muscle (at protein level)

Properties

SIZE: entity length = 1063 aa MW = 117 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-38} FG-GAP {54-117} MOTIF: N-glycosylation site {N81} cysteine residue {C96} MODIFICATION: cysteine residue {C106} cysteine residue {C106} MODIFICATION: cysteine residue {C96} N-glycosylation site {N122} FG-GAP {133-198} MOTIF: cysteine residue {C150} MODIFICATION: cysteine residue {C171} cysteine residue {C171} MODIFICATION: cysteine residue {C150} N-glycosylation site {N177} cysteine residue {C187} MODIFICATION: cysteine residue {C200} FG-GAP {199-263} MOTIF: cysteine residue {C200} MODIFICATION: cysteine residue {C187} N-glycosylation site {N239} FG-GAP {264-317} MOTIF: N-glycosylation site {N302} N-glycosylation site {N311} FG-GAP {318-383} MOTIF: Ca+2-binding site SITE: 329-337 FG-GAP {384-443} MOTIF: Ca+2-binding site SITE: 395-403 FG-GAP {447-501} MOTIF: Cell attachment site {455-457} Ca+2-binding site SITE: 459-467 N-glycosylation site {N504} cysteine residue {C507} MODIFICATION: cysteine residue {C518} cysteine residue {C518} MODIFICATION: cysteine residue {C507} cysteine residue {C524} MODIFICATION: cysteine residue {C580} cysteine residue {C580} MODIFICATION: cysteine residue {C524} N-glycosylation site {N601} N-glycosylation site {N605} cysteine residue {C641} MODIFICATION: cysteine residue {C647} cysteine residue {C647} MODIFICATION: cysteine residue {C641} cysteine residue {C713} MODIFICATION: cysteine residue {C726} N-glycosylation site {N719} cysteine residue {C726} MODIFICATION: cysteine residue {C713} N-glycosylation site {N737} N-glycosylation site {N753} N-glycosylation site {N780} cysteine residue {C867} MODIFICATION: cysteine residue {C-INTERCHAIN} N-glycosylation site {N896} N-glycosylation site {N923} cysteine residue {C929} MODIFICATION: cysteine residue {C934} cysteine residue {C934} MODIFICATION: cysteine residue {C929} N-glycosylation site {N1005} transmembrane domain {1013-1033}

Database Correlations

OMIM 604063 UniProt P53708 PFAM correlations Entrez Gene 8516 Kegg hsa:8516