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CD49b (integrin alpha-2, VLA-2 alpha chain or platelet membrane glycoprotein IA, ITGA2)

Function: - heterodimer with integrin beta-1 (integrin alpha-2/beta-1) - interacts with HPS5 Structure: - the integrin I-domain (insert) is a VWFA domain - integrins with I-domains do not undergo protease cleavage - belongs to the integrin alpha chain family - contains 7 FG-GAP repeats - contains 1 VWFA domain Compartment: membrane Pathology: - Lys-534 -> Glu-534 may play role in a) neonatal alloimmune thrombocytopenia b) coronary artery disease (CAD) Laboratory: - HPA-5 type in blood

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein integrin-alpha

Properties

SIZE: entity length = 1181 aa MW = 129 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-29} FG-GAP {45-103} MOTIF: cysteine residue {C83} MODIFICATION: cysteine residue {C92} cysteine residue {C92} MODIFICATION: cysteine residue {C83} consensus repeat {104} SEQUENCE-IS: FG-GAP N-glycosylation site {N105} N-glycosylation site {N112} VWFA domain {188-378} MOTIF: N-glycosylation site {N343} FG-GAP {379-433} MOTIF: N-glycosylation site {N432} FG-GAP {434-486} MOTIF: N-glycosylation site {N460} N-glycosylation site {N475} FG-GAP {488-549} MOTIF: Ca+2-binding site SITE: 499-507 FG-GAP {551-610} MOTIF: Ca+2-binding site SITE: 563-571 FG-GAP {615-667} MOTIF: Ca+2-binding site SITE: 627-635 cysteine residue {C680} MODIFICATION: cysteine residue {C737} N-glycosylation site {N699} cysteine residue {C737} MODIFICATION: cysteine residue {C680} cysteine residue {C789} MODIFICATION: cysteine residue {C795} cysteine residue {C795} MODIFICATION: cysteine residue {C789} cysteine residue {C865} MODIFICATION: cysteine residue {C876} cysteine residue {C876} MODIFICATION: cysteine residue {C865} cysteine residue {C1019} MODIFICATION: cysteine residue {C1050} cysteine residue {C1050} MODIFICATION: cysteine residue {C1019} cysteine residue {C1055} MODIFICATION: cysteine residue {C1060} N-glycosylation site {N1057} cysteine residue {C1060} MODIFICATION: cysteine residue {C1055} N-glycosylation site {N1074} N-glycosylation site {N1081} transmembrane domain {1133-1154} HPS5 interaction {1155-1161} MOTIF: GFFKR {1157-1161}

Database Correlations

OMIM 192974 UniProt P17301 PFAM correlations Entrez Gene 3673 Kegg hsa:3673

References

  1. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
  2. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 769
  3. Entrez Gene :accession 3673
  4. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ITGA2
  5. SeattleSNPs http://pga.gs.washington.edu/data/itga2/
  6. UniProt :accession P17301

Component-of

very late antigen 2 (VLA-2, integrin alpha-2/beta-1)