integrin alpha-11 (ITGA11)

Function: - associates with integrin beta-1 (integrin alpha-11/beta-1) Structure: - integrin I-domain (insert) is a VWFA domain - integrins with I-domains do not undergo protease cleavage - belongs to the integrin alpha chain family - contains 7 FG-GAP repeats - contains 1 VWFA domain Compartment: membrane Expression: - expressed in uterus, heart > skeletal muscle > pancreas, kidney & placenta - also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands & prostate - very low levels in peripheral blood lymphocytes, fetal brain & fetal liver - strongly up-regulated in differentiating fetal muscle cells (in vitro)

Properties

SIZE: entity length = 1189 aa MW = 134 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-22} FG-GAP {38-94} MOTIF: cysteine residue {C76} MODIFICATION: cysteine residue {C83} N-glycosylation site {N82} cysteine residue {C83} MODIFICATION: cysteine residue {C76} N-glycosylation site {N95} FG-GAP {102-163} MOTIF: cysteine residue {C121} MODIFICATION: cysteine residue {C139} cysteine residue {C129} MODIFICATION: cysteine residue {C159} cysteine residue {C139} MODIFICATION: cysteine residue {C121} cysteine residue {C159} MODIFICATION: cysteine residue {C129} VWFA domain {164-345} MOTIF: N-glycosylation site {N291} N-glycosylation site {N331} N-glycosylation site {N358} FG-GAP {359-420} FG-GAP {422-475} MOTIF: N-glycosylation site {N449} N-glycosylation site {N462} FG-GAP {477-537} MOTIF: Ca+2-binding site SITE: 488-496 N-glycosylation site {N528} FG-GAP {539-598} MOTIF: Ca+2-binding site SITE: 551-559 FG-GAP {601-653} MOTIF: Ca+2-binding site SITE: 613-621 N-glycosylation site {N642} cysteine residue {C659} MODIFICATION: cysteine residue {C668} cysteine residue {C668} MODIFICATION: cysteine residue {C659} cysteine residue {C674} MODIFICATION: cysteine residue {C729} N-glycosylation site {N694} cysteine residue {C729} MODIFICATION: cysteine residue {C674} cysteine residue {C781} MODIFICATION: cysteine residue {C787} cysteine residue {C787} MODIFICATION: cysteine residue {C781} N-glycosylation site {N857} cysteine residue {C881} MODIFICATION: cysteine residue {C893} cysteine residue {C893} MODIFICATION: cysteine residue {C881} N-glycosylation site {N894} N-glycosylation site {N973} N-glycosylation site {N1032} N-glycosylation site {N1040} N-glycosylation site {N1060} transmembrane domain {1143-1165} arginine-rich region {1174-1177} MOTIF: arginine residue (SEVERAL)

Database Correlations

OMIM 604789 UniProt Q9UKX5 PFAM correlations Entrez Gene 22801 Kegg hsa:2280