integrin alpha-10 (ITGA10)

Function: - associates with integrin beta-1 (integrin alpha-10/beta-1) Structure: - the integrin I-domain (insert) is a VWFA domain - integrins with I-domains do not undergo protease cleavage - belongs to the integrin alpha chain family - contains 7 FG-GAP repeats - contains 1 VWFA domain Compartment: membrane Alternative splicing: named isoforms=2 Expression: - widely expressed - highest expression in muscle & heart - found in articular cartilage

Properties

SIZE: entity length = 1167 aa MW = 128 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-22} FG-GAP {38-97} MOTIF: cysteine residue {C76} MODIFICATION: cysteine residue {C86} cysteine residue {C86} MODIFICATION: cysteine residue {C76} consensus repeat {98} SEQUENCE-IS: FG-GAP N-glycosylation site {N98} VWFA domain {167-350} MOTIF: N-glycosylation site {N234} N-glycosylation site {N336} N-glycosylation site {N364} FG-GAP {365-427} FG-GAP {428-482} FG-GAP {483-545} MOTIF: Ca+2-binding site SITE: 494-502 FG-GAP {546-605} MOTIF: Ca+2-binding site SITE: 558-566 FG-GAP {608-660} MOTIF: Ca+2-binding site SITE: 620-628 cysteine residue {C666} MODIFICATION: cysteine residue {C675} cysteine residue {C675} MODIFICATION: cysteine residue {C666} cysteine residue {C681} MODIFICATION: cysteine residue {C736} N-glycosylation site {N733} cysteine residue {C736} MODIFICATION: cysteine residue {C681} N-glycosylation site {N763} cysteine residue {C789} MODIFICATION: cysteine residue {C795} cysteine residue {C795} MODIFICATION: cysteine residue {C789} N-glycosylation site {N839} N-glycosylation site {N921} N-glycosylation site {N1011} N-glycosylation site {N1018} N-glycosylation site {N1039} transmembrane domain {1123-1145}

Database Correlations

OMIM 604042 UniProt O75578 PFAM correlations Entrez Gene 8515 Kegg hsa:8515