CD49a; integrin alpha-1; CD49 antigen-like family member A; laminin & collagen receptor; VLA-1 (ITGA1)

Function: - heterodimer with integrin beta-1 (integrin alpha-1/beta-1) - recognizes proline-hydroxylated sequence G-F-P-G-E-R in collagen - interacts with RAB21 Structure: - integrin I-domain (insert) is a VWFA domain - integrins with I-domains do not undergo protease cleavage - belongs to the integrin alpha chain family - contains 7 FG-GAP repeats - contains 1 VWFA domain Compartment: membrane Expression: - activated T cells & B cells - monocytes

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen human longevity protein integrin-alpha

Properties

SIZE: entity length = 1179 aa MW = 131 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-28} FG-GAP {44-103} MOTIF: N-glycosylation site {N74} cysteine residue {C82} MODIFICATION: cysteine residue {C92} cysteine residue {C92} MODIFICATION: cysteine residue {C82} N-glycosylation site {N100} consensus repeat {104} SEQUENCE-IS: FG-GAP N-glycosylation site {N105} N-glycosylation site {N112} VWFA domain {147-360} MOTIF: N-glycosylation site {N217} N-glycosylation site {N317} N-glycosylation site {N341} FG-GAP {349-404} MOTIF: N-glycosylation site {N402} FG-GAP {405-457} MOTIF: N-glycosylation site {N418} FG-GAP {459-520} MOTIF: N-glycosylation site {N460} Ca+2-binding site SITE: 498-506 N-glycosylation site {N532} FG-GAP {540-599} MOTIF: Ca+2-binding site SITE: 580-588 FG-GAP {602-654} MOTIF: Ca+2-binding site SITE: 642-650 cysteine residue {C688} MODIFICATION: cysteine residue {C697} cysteine residue {C697} MODIFICATION: cysteine residue {C688} N-glycosylation site {N699} cysteine residue {C703} MODIFICATION: cysteine residue {C756} N-glycosylation site {N748} cysteine residue {C756} MODIFICATION: cysteine residue {C703} N-glycosylation site {N780} cysteine residue {C808} MODIFICATION: cysteine residue {C814} cysteine residue {C814} MODIFICATION: cysteine residue {C808} N-glycosylation site {N840} cysteine residue {C878} MODIFICATION: cysteine residue {C886} N-glycosylation site {N883} cysteine residue {C886} MODIFICATION: cysteine residue {C878} N-glycosylation site {N908} N-glycosylation site {N915} N-glycosylation site {N939} N-glycosylation site {N966} N-glycosylation site {N974} N-glycosylation site {N1008} cysteine residue {C1030} MODIFICATION: cysteine residue {C1062} cysteine residue {C1062} MODIFICATION: cysteine residue {C1030} cysteine residue {C1065} MODIFICATION: cysteine residue {C1072} cysteine residue {C1072} MODIFICATION: cysteine residue {C1065} N-glycosylation site {N1073} N-glycosylation site {N1083} N-glycosylation site {N1102} N-glycosylation site {N1113} transmembrane domain {1142-1164} GFFKR {1167-1171}

Database Correlations

OMIM 192968 UniProt P56199 PFAM correlations Entrez Gene 3672 Kegg hsa:3672