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integrin-alpha

Function: - ligand-binding subunit of integrins - regulates the specificity of ligand-dependent interactions Structure: - composed of alpha & beta subunits selected from 16 alpha & 8 beta subunits that heterodimerize to produce more than 20 different receptors [3] - the short cytoplasmic domains of the alpha & beta subunits do not have intrinsic enzyme activity, but appear to function by nucleating large complexes of cytoskeletal proteins & cytoskeletal-associated protein kinases - integrin beta-4 is the exception, with a cytoplasmic domain in excess of 1000 residues - integrin-alpha(s) contain highly divergent amino acid sequences, whereas the integrin-beta subunits show partial sequence conservation - the integrin-beta(s) target integrins to focal adhesions in a ligand-independent manner, whereas the integrin-alpha(s) regulate the specificity of ligand-dependent interactions

Specific

CD103 (integrin alpha-E, mucosal lymphocyte-1 antigen, HML-1 antigen, human mucosal lymphocyte antigen 1 antigen, ITGAE) CD11 CD41; integrin alpha-IIb; platelet membrane glycoprotein IIb (ITGA2B, GP2B, ITGAB) CD49a; integrin alpha-1; CD49 antigen-like family member A; laminin & collagen receptor; VLA-1 (ITGA1) CD49b (integrin alpha-2, VLA-2 alpha chain or platelet membrane glycoprotein IA, ITGA2) CD49c (integrin-alpha 3, VLA-3 alpha chain, galactoprotein-B3, GAPB3, ITGA3) CD49d (integrin alpha-4, VLA-4 alpha chain, ITGA4) CD49e (integrin alpha-5, integrin alpha-F, fibronection receptor alpha subunit, ITGA5) CD49f (integrin alpha-6, integrin alpha-F, ITGA6) CD51 (integrin alpha-V, vitronectin receptor alpha chain, ITGAV, MSK8, VNRA) integrin alpha-10 (ITGA10) integrin alpha-11 (ITGA11) integrin alpha-7 (ITGA7) integrin alpha-8 (ITGA8) integrin alpha-9 (integrin alpha-RLC, ITGA9)

General

cytoskeletal protein plasma membrane protein protein subunit

Properties

MOTIF: cysteine residue {CYS1} MODIFICATION: cysteine residue {CYS2} cysteine residue {CYS2} MODIFICATION: cysteine residue {CYS1} transmembrane domain kxgffkr NAME: kxgffkr SITE: cytoplasmic domain FOR-BINDING-OF: calreticulin FORM: kxgffkr

References

  1. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
  2. Burns K et al Modulation of gene expression by calreticulin binding to glucocorticoid receptor. Nature 367:476 1994 PMID: 8107808 {KXGFFKR}
  3. Dedhar et al Inhibition of nuclear hormone receptor activity by calreticulin. Nature 367:480 1994 PMID: 8107809 {KXGFFKR}
  4. Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: 7716514

Component-of

CD49 or Very Late Antigen (VLA)