integrator complex subunit 6 (Int6, INTS6, protein deleted in cancer 1, protein DDX26, DBI-1, DBI1, DDX26, DDX26A)

Function: 1) component of the integrator complex 2) role in tumor suppression (putative) - ectopic expression suppresses tumor cell growth Structure: - contains 1 VWFA domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - widely expressed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas Pathology: - frequently down-regulated in non small cell lung carcinomas & prostate cancers - down-regulation in prostate cancer is due to CpG hypermethylation of its promoter

Properties

SIZE: MW = 100 kD entity length = 887 aa COMPARTMENT: cell nucleus MOTIF: VWFA domain {3-227}

Database Correlations

OMIM 604331 UniProt Q9UL03

References

UniProt :accession Q9UL03