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integrator complex subunit 2 (Int2, INTS2, KIAA1287)
Function:
- component of the integrator complex
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure: belongs to the integrator subunit 2 family
Compartment: nucleus, membrane
Note:
- uncertain whether Met-1 or Met-9 is the initiator
- orthologous sequences (mouse & chicken) have shorter N-terminus
General
membrane protein
phosphoprotein
protein subunit
Properties
SIZE: entity length = 1204 aa
MW = 134 kD
COMPARTMENT: cell nucleus
MOTIF: transmembrane domain {428-444}
Tyr phosphorylation site {Y848}
Thr phosphorylation site {T849}
Database Correlations
UniProt Q9H0H0
References
UniProt :accession Q8N201
Component-of
integrator complex (multiprotein complex integrator)