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integrator complex (multiprotein complex integrator)
Function:
1) associated with C-terminal domain (CTD) of RNA polymerase 2 largest subunit (POLR2A)
2) recruited to U1 & U2 snRNAs genes
3) mediates the snRNAs 3' cleavage
4) role in small nuclear RNAs (snRNA) U1 & U2 transcription & 3' box-dependent processing
General
molecular complex
nuclear protein
Properties
COMPARTMENT: cell nucleus
SUBUNITS: integrator complex subunit 1
MOTIF: alanine-rich region {61-64}
MOTIF: alanine residue (SEVERAL)
transmembrane domain {1159-1179}
Ser phosphorylation site {S1326}
Ser phosphorylation site {S1327}
integrator complex subunit 2
MOTIF: transmembrane domain {428-444}
Tyr phosphorylation site {Y848}
Thr phosphorylation site {T849}
integrator complex subunit 3
MOTIF: glycine-rich region {9-34}
Ser phosphorylation site {S502}
integrator complex subunit 4
MOTIF: HEAT repeat {66-105}
HEAT repeat {145-183}
HEAT repeat {190-228}
HEAT repeat {229-263}
HEAT repeat {277-313}
HEAT repeat {369-405}
HEAT repeat {406-444}
HEAT repeat {446-484}
Thr phosphorylation site {T801}
integrator complex subunit 5
MOTIF: transmembrane domain {534-554}
transmembrane domain {856-876}
transmembrane domain {930-950}
Ser phosphorylation site {S1010}
integrator complex subunit 6
MOTIF: VWFA domain {3-227}
integrator complex subunit 7
MOTIF: phosphorylation site
glutamine-rich region {937-955}
MOTIF: glutamine residue (SEVERAL)
integrator complex subunit 8
MOTIF: Thr phosphorylation site {T18}
tetratricopeptide repeat {250-288}
tetratricopeptide repeat {320-356}
tetratricopeptide repeat {570-603}
tetratricopeptide repeat {833-866}
integrator complex subunit 9
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
integrator complex subunit 10
MOTIF: Ser phosphorylation site {S231}
integrator complex subunit 11
MOTIF: HXHXDH {68-73}
integrator complex subunit 12
MOTIF: Ser phosphorylation site {S128}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 159-215
EFFECTOR-BOUND: Zn+2
serine-rich region {270-440}
MOTIF: serine residue (SEVERAL)
References
UniProt :accession P61201, Q5TA45
Components
integrator complex subunit 1 (int1, INTS1, KIAA1440, UNQ1821/PRO3434)
integrator complex subunit 10 (Int10, INTS10, C8orf35)
integrator complex subunit 10 (Int9, INTS9, protein related to CPSF subunits of 74 kD, RC-74, RC74)
integrator complex subunit 11 (Int11, INTS11, CPSF3L-like protein, protein related to CPSF subunits of 68 kD, RC-68, CPSF3L, RC68)
integrator complex subunit 12 (PHD finger protein 22, Int12, INTS12, PHF22, SBBI22)
integrator complex subunit 2 (Int2, INTS2, KIAA1287)
integrator complex subunit 3 (Int3, INTS3, C1orf60)
integrator complex subunit 4(Int4, INTS4)
integrator complex subunit 5 (Int5, INTS5, KIAA1698)
integrator complex subunit 6 (Int6, INTS6, protein deleted in cancer 1, protein DDX26, DBI-1, DBI1, DDX26, DDX26A)
integrator complex subunit 7 (Int7, INTS7, C1orf73)
integrator complex subunit 8 (Int8, INTS8, KAONASHI protein 1, KAONASHI1, C8orf52)