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insulin receptor-related protein; IR-related receptor; contains: insulin receptor-related protein alpha chain & insulin receptor-related protein beta chain (INSRR, IRR)
Function:
- probably binds an insulin related protein
- has a tyrosine-protein kinase activity
- phosphorylates insulin receptor substrates IRS-1 & IRS-2
Structure:
- probable tetramer of 2 alpha & 2 beta chains linked by disulfide bonds
- the alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain
- belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
- contains 4 fibronectin F3 modules
- contains 1 protein kinase domain
Compartment: membrane
General
glycoprotein
tyrosine kinase receptor (RTK)
Properties
SIZE: entity length = 1297 aa
MW = 144 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-26}
N-glycosylation site {N47}
cysteine residue {C214}
MODIFICATION: cysteine residue {C222}
cysteine residue {C216}
MODIFICATION: cysteine residue {C228}
cysteine residue {C222}
MODIFICATION: cysteine residue {C214}
cysteine residue {C228}
MODIFICATION: cysteine residue {C216}
cysteine residue {C229}
MODIFICATION: cysteine residue {C237}
cysteine residue {C233}
MODIFICATION: cysteine residue {C246}
cysteine residue {C237}
MODIFICATION: cysteine residue {C229}
cysteine residue {C246}
MODIFICATION: cysteine residue {C233}
cysteine residue {C249}
MODIFICATION: cysteine residue {C258}
cysteine residue {C258}
MODIFICATION: cysteine residue {C249}
cysteine residue {C262}
MODIFICATION: cysteine residue {C274}
cysteine residue {C274}
MODIFICATION: cysteine residue {C262}
cysteine residue {C280}
MODIFICATION: cysteine residue {C300}
cysteine residue {C300}
MODIFICATION: cysteine residue {C280}
cysteine residue {C304}
MODIFICATION: cysteine residue {C317}
N-glycosylation site {N311}
cysteine residue {C317}
MODIFICATION: cysteine residue {C304}
cysteine residue {C320}
MODIFICATION: cysteine residue {C324}
cysteine residue {C324}
MODIFICATION: cysteine residue {C320}
N-glycosylation site {N411}
fibronectin type III domain or F3 module {484-594}
MOTIF: N-glycosylation site {N492}
N-glycosylation site {N528}
fibronectin type III domain or F3 module {605-686}
MOTIF: N-glycosylation site {N616}
N-glycosylation site {N634}
cysteine residue {C657}
MODIFICATION: cysteine residue {C-INTERCHAIN}
fibronectin type III domain or F3 module {724-805}
MOTIF: N-glycosylation site {N756}
fibronectin type III domain or F3 module {815-909}
MOTIF: N-glycosylation site {N885}
N-glycosylation site {N898}
transmembrane domain {922-943}
kinase domain
SITE: 979-1254
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 985-993
ATP-binding site
NAME: ATP-binding site
SITE: 1013-1013
aspartate residue {D1115}
Tyr phosphorylation site {Y1145}
Database Correlations
OMIM 147671
UniProt P14616
PFAM correlations
Kegg hsa:3645
ENZYME 2.7.10.1
References
UniProt :accession P14616