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insulin-like peptide INSL5; insulin-like peptide 5 (INSL5)
Function:
- role in gut contractility or thymic development ?
- activates RXFP4 with high potency
- appears to be the endogenous ligand for RXFP4
Structure:
- heterodimer of a B chain & an A chain linked by 2 disulfide bonds
- belongs to the insulin family
Compartment: secreted
Expression:
- highly expressed in rectum
- lower expression in uterus & colon
General
protein precursor
secreted protein
Properties
SIZE: MW = 15 kD
entity length = 135 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
cysteine residue {C29}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C41}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C121}
MODIFICATION: cysteine residue {C126}
cysteine residue {C126}
MODIFICATION: cysteine residue {C121}
Database Correlations
OMIM 606413
UniProt Q9Y5Q6
Pfam PF00049
Entrez Gene 10022
Kegg hsa:10022
References
UniProt :accession Q9Y5Q6