insulin-like growth factor-binding protein-like 1 (insulin-like growth factor-binding-related protein 4, IGFBP-related protein 10, IGFBP-rP4, IGFBPL1, IGFBPRP4)

Function: - IGF-binding proteins prolong the half-life of IGFs & either inhibit or stimulate the growth promoting effects of the IGFs in cell culture; they alter interaction of IGFs with their cell surface receptors - putative tumor suppressor protein Structure: - contains 1 Ig-like C2-type domain (immunoglobulin-like) - contains 1 IGFBP N-terminal domain - contains 1 Kazal-like domain Compartment: secreted Expression: - expressed brain & testis > prostate, bladder & lung - down-regulated in multiple tumors

Properties

SIZE: entity length = 278 aa MW = 29 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-25} IGFBP N-terminal {34-109} Kazal-type serine protease inhibitor domain {110-151} MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+X4} cysteine residue {X+X1} MODIFICATION: cysteine residue {X+X3} cysteine residue {X+X2} MODIFICATION: cysteine residue {X+X5} cysteine residue {X+X3} MODIFICATION: cysteine residue {X+X1} cysteine residue {X+X4} MODIFICATION: cysteine residue {X+0} cysteine residue {X+X5} MODIFICATION: cysteine residue {X+X2} FOR-BINDING-OF: serine protease binding site FOR-BINDING-OF: somatomedin immunoglobulin superfamily domain {155-259} MOTIF: N-glycosylation site {N166} cysteine residue {C176} MODIFICATION: cysteine residue {C243} cysteine residue {C243} MODIFICATION: cysteine residue {C176} SECRETED-BY: hepatocyte smooth muscle

Database Correlations

UniProt Q8WX77 PFAM correlations

References

UniProt :accession Q8WX77