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insulin-like 3 (Leydig insulin-like peptide, Ley-I-L, relaxin-like factor, [contains: insulin-like 3 B chain; insulin-like 3 A chain], INSL3, RLF, RLNL)
Function:
1) role in testicular function
2) trophic hormone with a role in testicular descent in fetal life (putative)
3) ligand for LGR8 receptor
Structure:
1) belongs to the insulin family
2) heterodimer of B chain & A chain linked by 2 disulfide bonds
Compartment: secreted
Expression:
- expressed in prenatal & postnatal Leydig cells
- expressed in corpus luteum, trophoblast, fetal membranes & breast
Pathology:
- defects in INSL3 seems to be a cause of cryptorchidism frequency of INSL3 gene mutations as a cause of cryptorchidism is low
General
secreted protein
Properties
SIZE: MW = 14 kD
entity length = 131 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
cysteine residue {C34}
MODIFICATION: cysteine residue {C46}
cysteine residue {C46}
MODIFICATION: cysteine residue {C34}
cysteine residue {C115}
MODIFICATION: cysteine residue {C120}
cysteine residue {C120}
MODIFICATION: cysteine residue {C115}
Database Correlations
OMIM correlations
MORBIDMAP 146738
UniProt P51460
Pfam PF00049
References
UniProt :accession P51460