inositol-trisphosphate 3-kinase C; inositol 1,4,5-trisphosphate 3-kinase C; IP3 3-kinase C; IP3K C; insP 3-kinase C (ITPKC, IP3KC)

Function: 1) phosphorylation of Ins(1,4,5)P3 to yield Ins(1,3,4,5)P4 2) also phosphorylates Ins(2,4,5)P3 to yield Ins(2,3,4,5)P4 3) activated by Ca⁺²/calmodulin 4) inhibited by high concentrations of substrate Ins(1,2,4)P3, 5) allosteric activation by the product Ins(1,3,4,5)P4 Compartment: - shuttles actively between nucleus & cytoplasm - associated with both import & export activity Expression: - expressed in pancreas, skeletal muscle, liver, placenta > kidney, brain Pathology: - defects in ITPKC are a cause of Kawasaki disease

General

kinase or ATP-phosphotransferase nuclear protein

Properties

SIZE: entity length = 683 aa MW = 75 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: nuclear export signal {324-332} ATP-binding site NAME: ATP-binding site SITE: 431-431 ATP-binding site NAME: ATP-binding site SITE: 471-473 ATP-binding site NAME: ATP-binding site SITE: 484-484 binding site SITE: 486-486 FOR-BINDING-OF: Substrate Substrate binding {507-513} calmodulin binding site SITE: 509-517 FOR-BINDING-OF: calmodulin Substrate binding {534-541} ATP-binding site NAME: ATP-binding site SITE: 558-558 ATP-binding site NAME: ATP-binding site SITE: 638-638 binding site SITE: 641-641 FOR-BINDING-OF: Substrate

Database Correlations

OMIM correlations MORBIDMAP 606476 UniProt Q96DU7 Pfam PF03770 Entrez Gene 80271 Kegg hsa:80271 ENZYME 2.7.1.127

References

UniProt :accession Q96DU7