inositol transporter SLC5A3 (Na+/myo-inositol cotransporter, solute carrier family 5 member 3, SLC5A3)

Function: - prevents intracellular accumulation of high concentrations of myo-inositol - Na⁺ is co-tranported with myo-inositol Structure: - belongs to the Na⁺:solute symporter (SSF) (TC 2.A.21) family Compartment: membrane

General

glycoprotein solute carrier family 5 (SLC5, SLC5A) symporter

Properties

SIZE: MW = 80 kD entity length = 718 aa COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-9} transmembrane domain {10-29} exoplasmic loop {30-38} MOTIF: N-glycosylation site {N32} transmembrane domain {39-57} cytoplasmic loop {58-86} transmembrane domain {87-110} exoplasmic loop {111-123} transmembrane domain {124-144} cytoplasmic loop {145-157} transmembrane domain {158-183} exoplasmic loop {184-186} transmembrane domain {187-205} cytoplasmic loop {206-303} transmembrane domain {304-324} exoplasmic loop {325-353} transmembrane domain {354-376} cytoplasmic loop {377-406} transmembrane domain {407-430} exoplasmic loop {431-443} transmembrane domain {444-462} cytoplasmic loop {463-510} transmembrane domain {511-532} exoplasmic loop {533-695} transmembrane domain {696-716} cytoplasmic domain {717-718}

Database Correlations

OMIM 600444 UniProt P53794 Pfam PF00474 Entrez Gene 6526 Kegg hsa:6526