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inositol polyphosphate multikinase; inositol 1,3,4,6-tetrakisphosphate 5-kinase (IPMK, IMPK)
Function:
1) Inositol phosphate kinase with broad substrate specificity
2) preference for inositol-1,4,5-trisphosphate & inositol 1,3,4,6-tetrakisphosphate
Compartment: nuclear
Expression:
- ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, leukocytes, kidney, spleen & colon
General
kinase or ATP-phosphotransferase
nuclear protein
Properties
SIZE: entity length = 416 aa
MW = 47 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S7}
Thr phosphorylation site {T21}
Ser phosphorylation site {S22}
Substrate binding {140-148}
nuclear translocation signal {320-330}
Ser phosphorylation site {S348}
Ser phosphorylation site {S350}
Database Correlations
OMIM 609851
UniProt Q8NFU5
Pfam PF03770
Entrez Gene 253430
Kegg hsa:253430
ENZYME 2.7.1.151
References
UniProt :accession Q8NFU5