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inositol-pentakisphosphate 2-kinase; IPK1 homolog; inositol-1,3,4,5,6-pentakisphosphate 2-kinase; ins(1,3,4,5,6)P5 2-kinase; insP5 2-kinase (IPPK, C9orf12)
Function:
- phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate)
Kinetic parameters:
- KM=0.43 uM for ins(1,3,4,5,6)P5
- KM=21 uM for ATP
- Vmax=31 nmol/min/mg enzyme
Structure:
- the EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 & 2
- belongs to the IPK1 type 2 family
Compartment: nuclear & cytoplasmic
Expression:
- ubiquitously expressed
- high expression in heart, brain, testis & placenta
Interactions
molecular events
General
kinase or ATP-phosphotransferase
Properties
SIZE: entity length = 491 aa
MW = 56 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: EXKPK {136-140}
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
Database Correlations
UniProt Q9H8X2
Pfam PF06090
Entrez Gene 64768
Kegg hsa:64768
ENZYME 2.7.1.158
References
- UniProt :accession Q9H8X2