inositol hexakisphosphate kinase 2; insP6 kinase 2; P(i)-uptake stimulator; PiUS (IP6K2, IHPK2, TCCCIA00113)

Function: - converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) - converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 Structure: belongs to the inositol phosphokinase (IPK) family Compartment: nucleus Alternative splicing: - named isoforms=3 - at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

General

inositol hexaphosphate kinase (IHPK) nuclear protein

Properties

SIZE: entity length = 426 aa MW = 49 kD COMPARTMENT: cell nucleus MOTIF: Substrate binding {216-224}

Database Correlations

OMIM 606992 UniProt Q9UHH9 Pfam PF03770 Entrez Gene 51447 Kegg hsa:51447 ENZYME 2.7.4.21

References

UniProt :accession Q9UHH9