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NAD kinase; poly(P)/ATP NAD kinase (NADK)
Function:
- phosphorylates NAD+
ATP + NAD+ = ADP + NADP+
Cofactor: divalent metal cations
Kinetic parameters:
- KM=3.3 mM for ATP
- KM=0.54 mM for NAD
- Vmax=6.7 umol/min/mg enzyme
- pH dependence: optimum pH is 7.5
- temperature dependence: optimum temperature is 55 degrees C
Structure:
- belongs to the NAD kinase family
Expression:
- widely expressed
- not detected in skeletal muscle
General
kinase or ATP-phosphotransferase
Properties
SIZE: entity length = 446 aa
MW = 49 kD
MOTIF: Ser phosphorylation site {S46}
Ser phosphorylation site {S48}
Ser phosphorylation site {S50}
Ser phosphorylation site {S64}
alanine-rich region {326-333}
MOTIF: alanine residue (SEVERAL)
glutamate-rich region {437-445}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 611616
UniProt O95544
Pfam PF01513
Entrez Gene 65220
Kegg hsa:65220
ENZYME 2.7.1.23
References
UniProt :accession O95544