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innate immunity activator protein (INAVA, C1orf106)

Function: - required for optimal pattern recognition receptor-induced signaling, cytokine secretion, & bacterial clearance - in the intestine, regulates adherens junction stability by regulating degradation of CYTH1 & CYTH2 as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes - stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation Alternative splicing: named isoforms=2 Expression: - peripheral macrophages - intestinal myeloid-derived cells Pathology: - genetic variations in INAVA are associated with an increased risk of inflammatory bowel disease [3]

General

nuclear protein

Properties

SIZE: entity length = 663 aa MW = 73 kD COMPARTMENT: cell nucleus MOTIF: coiled coil {118-147} nuclear translocation signal {164-170} proline-rich region SITE: 282-357 MOTIF: proline residue (SEVERAL) nuclear translocation signal {332-338} nuclear translocation signal {422-428}

Database Correlations

UniProt Q3KP66

References

  1. UniProt :accession Q3KP66
  2. Yan J, Hedl M, Abraham C. An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes. J Clin Invest. 2017 Jun 1;127(6):2192-2205. PMID: 28436939 Free PMC Article
  3. Mohanan V, Nakata T, Desch AN et al C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science. 2018 Mar 9;359(6380):1161-1166. PMID: 29420262