inhibitor of nuclear factor kappa-B kinase-interacting protein; I kappa-B kinase interacting protein; IKK-interacting protein (IKIP, IKBIP)

Function: - target of TP53/p53 with pro-apoptotic function - isoform 4 may be phosphorylated at Thr-362 by similarity with mouse isoform 1 (Ikip1) - N-glycosylated - isoform 4 is glycosylated at Asn-154 Compartment: - endoplasmic reticulum membrane - isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization Alternative splicing: named isoforms=4 Expression: - expressed in vein endothelial cells - isoform 4 is expressed in lung, kidney, spleen, thymus & skeletal muscle - induced by X-irradiation Genetics: - IKIP gene shares a common promoter with APAF1 from which the 2 genes are transcribed in the opposite direction Note: variant in position: 122:Q->H (in dbSNP:rs12322444)

General

glycoprotein membrane protein

Properties

SIZE: entity length = 350 aa MW = 39 kD COMPARTMENT: endoplasmic reticulum MOTIF: transmembrane domain {46-62} N-glycosylation site {N144} coiled coil {184-217} N-glycosylation site {N328}

References

UniProt :accession Q70UQ0