inhibitor of growth protein 2; inhibitor of growth 1-like protein; ING1Lp; p32; p33ING2 (ING2, ING1L)

Function: - seems to be involved in p53/TP53 activation & p53/TP53- dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53 - component of a msin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones - ING2 activity seems to be modulated by binding to phosphoinositides - interacts with H3K4me3 & to a lesser extent with H3K4me2 Structure: - the PHD-type Zn⁺² finger mediates the binding to H3K4me3 - the polybasic region (PBR) is responsive to the binding to phosphoinositides, including phosphatidylinositol-5-phosphate (Ptdins(5)P) - belongs to the ING family - contains 1 PHD-type Zn⁺² finger Compartment: - nucleus - predominantly nuclear - localized to chromatin & nuclear matrix - upon reduced Ptdins(5)P levels, seems to be released from chromatin &, at least partially, translocated to the cytoplasm Expression: - widely expressed - induced by the DNA-damaging agents etoposide & neocarzinostatin Pathology: - higher expression in colon-cancer than in normal colon

General

inhibitor of growth protein zinc finger protein

Properties

SIZE: entity length = 280 aa MW = 33 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: coiled coil {48-120} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 212-261 EFFECTOR-BOUND: Zn+2 MOTIF: binding site SITE: 214-214 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 225-225 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 229-229 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 237-237 FOR-BINDING-OF: Histone H3K4me3 PBR {264-280}

Database Correlations

OMIM 604215 UniProt Q9H160 PFAM correlations Entrez Gene 3622 Kegg hsa:3622

References

UniProt :accession Q9H160