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inhibin-B
Function:
- inhibits secretion of FSH
Compartment: secreted
Expression:
- secreted by ovarian granulosa cells & Sertoli cells of the testes in response to stimulation by FSH
General
inhibin
Properties
COMPARTMENT: extracellular compartment
SECRETED-BY: granulosa cell
WITHIN: ovary
sertoli cell
WITHIN: testis
SUBUNITS: inhibin alpha chain
MOTIF: signal sequence {1-18}
peptide motif {61-62}
N-glycosylation site {N146}
peptide motif {232-233}
cysteine residue {C262}
MODIFICATION: cysteine residue {C328}
N-glycosylation site {N268}
cysteine residue {C291}
MODIFICATION: cysteine residue {C363}
cysteine residue {C295}
MODIFICATION: cysteine residue {C365}
N-glycosylation site {N302}
cysteine residue {C327}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C328}
MODIFICATION: cysteine residue {C262}
cysteine residue {C363}
MODIFICATION: cysteine residue {C291}
cysteine residue {C365}
MODIFICATION: cysteine residue {C295}
inhibin beta B chain
MOTIF: signal sequence {1-28}
N-glycosylation site {N93}
cysteine residue {C296}
MODIFICATION: cysteine residue {C304}
cysteine residue {C303}
MODIFICATION: cysteine residue {C372}
cysteine residue {C304}
MODIFICATION: cysteine residue {C296}
cysteine residue {C332}
MODIFICATION: cysteine residue {C404}
cysteine residue {C336}
MODIFICATION: cysteine residue {C406}
cysteine residue {C371}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C372}
MODIFICATION: cysteine residue {C303}
cysteine residue {C404}
MODIFICATION: cysteine residue {C332}
cysteine residue {C406}
MODIFICATION: cysteine residue {C336}
References
Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
Components
inhibin alpha chain (INHA)
inhibin beta B chain; activin beta-B chain (INHBB)