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ingenol disoxate
diterpene ester extracted & purified from the plant Euphorbia peplus
Indications:
- actinic keratosis
Contraindications:
- do not use near lips or eyes
Dosage:
- applied on 2-3 consecutive days to large areas of the face, chest, & scalp
- developed for application to areas ranging up to 250 cm2 [1]
- use ingenol mebutate for areas < 25 cm2
Adverse effects:
- see ingenol mebutate
Mechanism of action:
- localized induction of necrosis followed by a transient inflammatory response
Related
ingenol mebutate (Picato)
General
dermatologic agent
pharmaceutical herb; medicinal herb; herbal supplement; botanical
diterpene
References
- Bankhead C
American Academy of Dermatology (AAD) 2017 Meeting Coverage
Brief, Broad-Area Treatment Clears Actinic Keratosis
- High patient satisfaction with ingenol disoxate
https://www.medpagetoday.com/Dermatology/SkinCancer/63706
- Siegel DM et al.
Safety and efficacy of ingenol disoxate 3-day field treatment
of actinic keratoses on face, chest, or balding scalp.
American Academy of Dermatology (AAD) 2017. Poster 4364.
- Berman B, et al
High patient satisfaction and improved cosmetic outcomes after
a 3-day field treatment of actinic keratosis with ingenol
disoxate on the fact, chest, and balding scalp.
American Academy of Dermatology (AAD) 2017. Poster 4358