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inflammasome

Function: - component of the innate immune response - activates defense system in anticipation of invasion - activation of proinflammatory caspases - release of cytokines Structure: - consists of: PYCARD, CARD8, CASP1, CIAS1, NLRP3

General

molecular complex

Properties

COMPARTMENT: cell nucleus SUBUNITS: apoptosis-associated speck-like protein containing a CARD COMPARTMENT: cytoplasm cell nucleus MOTIF: DAPIN domain {1-91} CARD domain {107-195} Caspase recruitment domain-containing protein 8 COMPARTMENT: cytoplasm cell nucleus MOTIF: CARD domain {340-430} caspase-1 COMPARTMENT: cytoplasm MOTIF: CARD domain {1-91} histidine residue {H237} cysteine residue {C285} NACHT, LRR & PYD domains-containing protein 3 COMPARTMENT: cytoplasm MOTIF: DAPIN domain {1-93} NACHT domain NAME: NACHT domain SITE: 220-536 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 226-233 glutamate-rich region {690-697} MOTIF: glutamate residue (SEVERAL) leucine-rich repeat SITE: 742-762 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 771-792 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 799-819 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 828-849 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 856-876 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 885-906 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 913-933 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 942-963 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 970-991 MOTIF: leucine residue (SEVERAL)

References

  1. UniProt :accession Q9NX02
  2. Martinon F, Patrilli V, Mayor A, Tardivel A, Tschopp J Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006 Mar 9;440(7081):237-41. Epub 2006 Jan 11. PMID: 16407889

Components

apoptosis-associated speck-like protein containing a CARD; hASC; caspase recruitment domain-containing protein 5; PYD & CARD domain-containing protein; target of methylation-induced silencing 1 (PYCARD, ASC, CARD5, TMS1) Caspase recruitment domain-containing protein 8; apoptotic protein NDPP1; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; DACAR; tumor up-regulated CARD-containing antagonist of CASP9; TUCAN (CARD8 KIAA0955 NDPP1) caspase-1; IL1 beta-converting enzyme [ICE] (CASP1, IL1BC, IL1BCE) NACHT, LRR & PYD domains-containing protein 3; angiotensin/vasopressin receptor AII/AVP-like; caterpiller protein 1.1; CLR1.1; cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1 (NLRP3, C1orf7, CIAS1, NALP3 ,PYPAF1)