inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8 (USP17L8)

Structure: - belongs to the peptidase C19 family, USP17 subfamily - probably inactive as an hydrolase due to the lack of catalytic His at position 334 Compartment: nucleus (putative) Note: - the RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17 - it is present with an interindividual variation in copy number & between 20 to 103 copies can be found in the genome both on chromosome 4 & chromosome 8

General

nuclear protein ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme

Properties

SIZE: entity length = 530 aa MW = 60 kD COMPARTMENT: cell nucleus MOTIF: active site MOTIF: cysteine residue

References

UniProt :accession P0C7I0