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inactive serine protease RAMP; regeneration-associated muscle protease homolog (RAMP, PAMR1)
Function:
- role in regeneration of skeletal muscle (putative)
Structure:
- belongs to the peptidase S1 family
- although related to peptidase S1 family, conserved active Ser residue in position 665 is replaced by Thr, thus thought to have no protease activity
- contains 1 CUB domain
- contains 1 EGF-like domain
- contains 1 peptidase S1 domain
- contains 2 Sushi domains (CCP/SCR domains)
Compartment: secreted
Alternative splicing: named isoforms=2
Pathology:
- strongly down-regulated in muscle cell lines derived from biopsies of 5 Duchenne muscular dystrophy (DMD) patients compared to a normal muscle cell line
General
glycoprotein
secreted protein
Properties
SIZE: MW = 80 kD
entity length = 720 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
cysteine-rich region {42-94}
CUB domain {128-236}
MOTIF: cysteine residue {C128}
MODIFICATION: cysteine residue {C150}
cysteine residue {C150}
MODIFICATION: cysteine residue {C128}
cysteine residue {C177}
MODIFICATION: cysteine residue {C199}
cysteine residue {C199}
MODIFICATION: cysteine residue {C177}
EGF domain {235-272}
MOTIF: cysteine residue {C239}
MODIFICATION: cysteine residue {C250}
cysteine residue {C244}
MODIFICATION: cysteine residue {C260}
cysteine residue {C250}
MODIFICATION: cysteine residue {C239}
cysteine residue {C260}
MODIFICATION: cysteine residue {C244}
cysteine residue {C262}
MODIFICATION: cysteine residue {C271}
cysteine residue {C271}
MODIFICATION: cysteine residue {C262}
Sushi domain {278-344}
MOTIF: cysteine residue {C280}
MODIFICATION: cysteine residue {C329}
cysteine residue {C315}
MODIFICATION: cysteine residue {C342}
cysteine residue {C329}
MODIFICATION: cysteine residue {C280}
cysteine residue {C342}
MODIFICATION: cysteine residue {C315}
Sushi domain {387-444}
MOTIF: cysteine residue {C414}
MODIFICATION: cysteine residue {C442}
cysteine residue {C442}
MODIFICATION: cysteine residue {C414}
S1 domain {445-720}
MOTIF: cysteine residue {C489}
MODIFICATION: cysteine residue {C505}
cysteine residue {C505}
MODIFICATION: cysteine residue {C489}
N-glycosylation site {N614}
cysteine residue {C630}
MODIFICATION: cysteine residue {C649}
cysteine residue {C649}
MODIFICATION: cysteine residue {C630}
cysteine residue {C661}
MODIFICATION: cysteine residue {C697}
cysteine residue {C697}
MODIFICATION: cysteine residue {C661}
Database Correlations
UniProt Q6UXH9
PFAM correlations
References
UniProt :accession Q6UXH9