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inactive group IIC secretory phospholipase A2 (phosphatidylcholine 2-acylhydrolase GIIC, PLA2G2C)
Function:
- inactive phospholipase (probable)
Cofactor: binds 1 Ca+2 per subunit (putative)
Structure:
- belongs to the phospholipase A2 family
- lacks typical His active site in position 68 that is replaced by a Ser preventing phospholipase activity
Compartment: secreted (putative)
Note: could be the product of a pseudogene
General
Ca+2 binding protein
secreted protein
Properties
SIZE: entity length = 150 aa
MW = 17 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-16}
cysteine residue {C47}
MODIFICATION: cysteine residue {C143}
Ca+2-binding site
SITE: 48-48
Ca+2-binding site
SITE: 50-50
Ca+2-binding site
SITE: 52-52
cysteine residue {C78}
MODIFICATION: cysteine residue {C108}
cysteine residue {C96}
MODIFICATION: cysteine residue {C113}
cysteine residue {C98}
MODIFICATION: cysteine residue {C106}
cysteine residue {C106}
MODIFICATION: cysteine residue {C98}
cysteine residue {C108}
MODIFICATION: cysteine residue {C78}
cysteine residue {C113}
MODIFICATION: cysteine residue {C96}
cysteine residue {C143}
MODIFICATION: cysteine residue {C47}
Database Correlations
UniProt Q5R387
Pfam PF00068
References
UniProt :accession Q5R387