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inactive dipeptidyl peptidase 10 (dipeptidyl peptidase X, dipeptidylpeptidase-like protein 2, DPL2, dipeptidyl peptidase IV-related protein 3, DPRP-3, DPP10, DPRP3, KIAA1492)
Function:
1) no dipeptidyl aminopeptidase activity
2) may modulate cell surface expression & activity of K+ channels KCND1 & KCND2
Structure:
- may form oligomers
- N-glycosylated
- belongs to the peptidase S9B family, DPPIV subfamily
Compartment: membrane
Alternative splicing:
- named isoforms=2
- additional isoforms seem to exist, which may have different subcellular locations
Expression:
- found in serum, T-cells & brain
- expressed in brain, pancreas, spinal cord, adrenal glands
Pathology:
- defects in DPP10 may be a cause of susceptibility to asthma defects in splicing have been observed
General
membrane protein
secreted protein
Properties
SIZE: MW = 91 kD
entity length = 796 aa
COMPARTMENT: cellular membrane
MOTIF: Mediates effects on KCND2 {1-56}
MOTIF: transmembrane domain {35-55}
N-glycosylation site {N63}
N-glycosylation site {N90}
N-glycosylation site {N111}
N-glycosylation site {N119}
N-glycosylation site {N257}
N-glycosylation site {N342}
N-glycosylation site {N748}
N-glycosylation site {N760}
Database Correlations
OMIM 608209
UniProt Q8N608
PFAM correlations
References
UniProt :accession Q8N608