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imprinted gene
Monoallelic expression or uniparental disomy. Imprinted genes display differential expression patterns & differential replication patterns of maternal & paternal alleles. Imprinted genes appear to be embedded in large DNA domains with differential expression & replication patterns, which may provide a structural imprint of parenteral identity.
Specific
CD81 or TAPA1 gene
CDKN1C or p57KIP2 gene
COL7A1 gene
Grb10 gene
IGF-2 gene
KVLQT1 gene
MITF (WS2A) gene
p73 gene
PAX3, WS1, HUP2 or CDHS gene
PEG10 gene
General
gene
Properties
MOTIF: transcription factor binding site
transcriptional start site
exon
intron
transcriptional termination site
References
- Rainier S, Johnson LA, Dobry CJ, Ping AJ, Grundy PE, Feinberg AP.
Relaxation of imprinted genes in human cancer.
Nature. 1993 Apr 22;362(6422):747-9.
PMID: 8385745
- Kitsberg D, Selig S, Brandeis M, Simon I, Keshet I,
Driscoll DJ, Nicholls RD, Cedar H.
Allele-specific replication timing of imprinted gene regions.
Nature. 1993 Jul 29;364(6436):459-63.
PMID: 8332218