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immunoglobulin superfamily member 5 (junctional adhesion molecule 4, IGSF5, JAM4)
Function:
- provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus & small intestinal epithelial cells
- mediates Ca+2-independent homophilic cell adhesion
- in testis, may function as a cell adhesion molecule rather than a tight-junction protein
- may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, & Sertoli cells- Sertoli cells (putative)
- interacts with MAGI1 at tight junctions, forms a tripartite complex with NPHS1 (putative)
- interacts with LNX1 isoform 2 via its PDZ 2 domain, may also interact with other isoforms containing this domain (putative)
Structure:
- belongs to the immunoglobulin superfamily
- contains 2 Ig-like V-type domain (immunoglobulin-like)
Compartment:
- cell membrane (putative)
- tight junction
General
glycoprotein
immunoglobulin superfamily protein
membrane protein
Properties
SIZE: entity length = 407 aa
MW = 45 kD
COMPARTMENT: cellular membrane
MOTIF: immunoglobulin superfamily domain {39-139}
MOTIF: N-glycosylation site {N59}
cysteine residue {C60}
MODIFICATION: cysteine residue {C123}
N-glycosylation site {N103}
cysteine residue {C123}
MODIFICATION: cysteine residue {C60}
immunoglobulin superfamily domain {142-231}
MOTIF: cysteine residue {C163}
MODIFICATION: cysteine residue {C215}
N-glycosylation site {N210}
cysteine residue {C215}
MODIFICATION: cysteine residue {C163}
N-glycosylation site {N231}
transmembrane domain {267-285}
cysteine-rich region {281-307}
Database Correlations
UniProt Q9NSI5
Pfam PF07679
References
UniProt :accession Q9NSI5