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immunoglobulin superfamily member 3 (EWI-3) (IGSF3, KIAA0466)
Structure:
- contains 8 Ig-like C2-type domain (immunoglobulin-like)
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in a wide range of tissues
- high expression in placenta, kidney & lung Misc
- likely interchromosomal Alu-mediated fusion between IGSF3 on 1p13.1 & GGT on 22q11.2.
- breakpoints occurred inside Alu elements as well as in the 5' or 3' ends of them
General
glycoprotein
immunoglobulin superfamily protein
membrane protein
Properties
SIZE: entity length = 1194 aa
MW = 135 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
immunoglobulin superfamily domain {20-138}
MOTIF: cysteine residue {C42}
MODIFICATION: cysteine residue {C120}
N-glycosylation site {N43}
cysteine residue {C120}
MODIFICATION: cysteine residue {C42}
immunoglobulin superfamily domain {143-262}
MOTIF: cysteine residue {C167}
MODIFICATION: cysteine residue {C246}
cysteine residue {C246}
MODIFICATION: cysteine residue {C167}
EWI {250-252}
immunoglobulin superfamily domain {276-386}
MOTIF: cysteine residue {C302}
MODIFICATION: cysteine residue {C376}
cysteine residue {C376}
MODIFICATION: cysteine residue {C302}
immunoglobulin superfamily domain {401-539}
MOTIF: N-glycosylation site {N418}
cysteine residue {C432}
MODIFICATION: cysteine residue {C511}
cysteine residue {C511}
MODIFICATION: cysteine residue {C432}
immunoglobulin superfamily domain {545-661}
MOTIF: cysteine residue {C566}
MODIFICATION: cysteine residue {C645}
cysteine residue {C645}
MODIFICATION: cysteine residue {C566}
N-glycosylation site {N655}
immunoglobulin superfamily domain {676-803}
MOTIF: cysteine residue {C701}
MODIFICATION: cysteine residue {C782}
cysteine residue {C782}
MODIFICATION: cysteine residue {C701}
immunoglobulin superfamily domain {813-945}
MOTIF: cysteine residue {C838}
MODIFICATION: cysteine residue {C918}
N-glycosylation site {N842}
cysteine residue {C918}
MODIFICATION: cysteine residue {C838}
immunoglobulin superfamily domain {949-1097}
MOTIF: cysteine residue {C974}
MODIFICATION: cysteine residue {C1080}
cysteine residue {C1080}
MODIFICATION: cysteine residue {C974}
transmembrane domain {1125-1145}
Database Correlations
OMIM 603491
UniProt O75054
PFAM correlations
Kegg hsa:3321
References
UniProt :accession O75054