immunoglobulin superfamily member 11 (brain & testis-specific immunoglobulin superfamily protein, Bt-IGSF, V-set & immunoglobulin domain-containing protein 3, IGSF11, BTIGSF, CXADRL1, VSIG3)

Function: - cell adhesion molecule through homophilic interaction - stimulates cell growth Structure: - N-glycosylated (putative) - contains 1 Ig-like C2-type domain (immunoglobulin-like) - contains 1 Ig-like V-type domain (immunoglobulin-like) - the last 20 cytoplasmic amino-acids are not required for cell adhesion Compartment: cell membrane Alternative splicing: named isoforms=3 Expression: - abundantly expressed in testis & ovary - expressed to a lower extent in brain, kidney & skeletal muscle

General

glycoprotein immunoglobulin superfamily protein membrane protein

Properties

SIZE: entity length = 431 aa MW = 46 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-22} immunoglobulin superfamily domain {23-136} MOTIF: cysteine residue {C44} MODIFICATION: cysteine residue {C120} N-glycosylation site {N102} cysteine residue {C120} MODIFICATION: cysteine residue {C44} immunoglobulin superfamily domain {144-234} MOTIF: cysteine residue {C165} MODIFICATION: cysteine residue {C215} cysteine residue {C215} MODIFICATION: cysteine residue {C165} transmembrane domain {242-262}

Database Correlations

OMIM 608351 UniProt Q5DX21 PFAM correlations Kegg hsa:1524

References

UniProt :accession Q5DX21