immunoglobulin superfamily containing leucine-rich repeat protein (ISLR)

Structure: - contains 1 Ig-like (immunoglobulin-like) domain - contains 6 LRR repeats (leucine-rich repeats) Compartment: secreted (putative) Expression: - expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach & spinal cord - expressed in fetal lung & kidney

General

immunoglobulin superfamily protein secreted protein

Properties

SIZE: entity length = 428 aa MW = 46 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-18} leucine-rich repeat SITE: 49-72 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 74-96 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 97-120 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 121-144 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 145-168 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 170-192 MOTIF: leucine residue (SEVERAL) immunoglobulin superfamily domain {232-343} MOTIF: cysteine residue {C257} MODIFICATION: cysteine residue {C327} cysteine residue {C327} MODIFICATION: cysteine residue {C257}

Database Correlations

OMIM 602059 UniProt O14498 PFAM correlations

References

UniProt :accession O14498