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CD179b; immunoglobulin lambda-like polypeptide 1; CD179 antigen-like family member B; Ig lambda-5; immunoglobulin omega polypeptide; immunoglobulin-related protein 14.1 (IGLL1, IGL1)
Function:
- critical for B-cell development
- associates non-covalently with VPREB1
Structure:
- contains 1 Ig-like C1-type (immunoglobulin-like) domain
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- expressed only in pre-B-cells & a special B-cell line (which is surface Ig negative)
Pathology:
- defects in IGLL1 are the cause of agammaglobulinemia type 2
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
secreted protein
Properties
SIZE: entity length = 213 aa
MW = 23 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-37}
J region {97-108}
C region {109-213}
MOTIF: immunoglobulin superfamily domain {114-208}
cysteine residue {C135}
MODIFICATION: cysteine residue {C194}
cysteine residue {C194}
MODIFICATION: cysteine residue {C135}
cysteine residue {C212}
MODIFICATION: cysteine residue {C-INTERCHAIN}
Database Correlations
OMIM correlations
MORBIDMAP 146770
UniProt P15814
Pfam PF07654
Entrez Gene 3543
Kegg hsa:3543
References
- UniProt :accession P15814
- IGLL1base; Note: IGLL1 mutation db
http://bioinf.uta.fi/IGLL1base/
- Wikipedia; Note: IGLL1
http://en.wikipedia.org/wiki/IGLL1