Radiation-inducible immediate-early gene IEX-1; immediate early protein GLY96; immediate early response 3 protein; PACAP-responsive gene 1 protein; protein PRG1; differentiation-dependent gene 2 protein; protein DIF-2 (IER3, DIF2, IEX1, PRG1)

Function: - may play a role in the ERK signaling pathway by inhibiting dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme - interacts with the PPP2R5C-PP2A holoenzyme & ERK kinases; regulates ERK dephosphorylation Structure: - glycosylated - belongs to the IER3 family Compartment: - membrane; single-pass type 2 membrane protein (putative) Expression: - induced by radiation, TPA, okadaic acid & TNF-alpha

General

glycoprotein membrane protein

Properties

SIZE: entity length = 156 aa MW = 17 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {83-99} N-glycosylation site {N133}

Database Correlations

OMIM 602996 UniProt P46695 Entrez Gene 8870 Kegg hsa:8870

References

UniProt :accession P46695